Human clinical trials and systematic reviews demonstrate that resveratrol, a polyphenol found in grapes and berries, supports multiple systems relevant to female health and aging. It improves endothelial and mitochondrial function, enhances insulin sensitivity, and reduces oxidative stress and inflammatory signaling. In women, studies show benefits for metabolic balance, bone density, cognitive performance, and vascular health, particularly during and after menopause. Through modulation of estrogen receptor pathways and activation of SIRT1 signaling, resveratrol promotes cellular longevity and homeostasis. Overall, clinical evidence supports its role as a multifunctional bioactive compound contributing to metabolic resilience, hormonal balance, and healthy aging in women.
Resveratrol is a key ingredient in Estro FORMULA.
Menopausal & Hormonal Health
1: Zhou DD, Luo M, Huang SY, Saimaiti A, Shang A, Gan RY, Li HB. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxid Med Cell Longev. 2021 Jul 11;2021:9932218. doi: 10.1155/2021/9932218. PMID: 34336123; PMCID: PMC8289612.
2: Ren B, Kwah MX, Liu C, Ma Z, Shanmugam MK, Ding L, Xiang X, Ho PC, Wang L, Ong PS, Goh BC. Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Lett. 2021 Sep 1;515:63-72. doi: 10.1016/j.canlet.2021.05.001. Epub 2021 May 28. PMID: 34052324.
3: Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019 Feb 28;66(1):13-21. doi: 10.18388/abp.2018_2749. PMID: 30816367.
4: Rauf A, Imran M, Butt MS, Nadeem M, Peters DG, Mubarak MS. Resveratrol as an anti-cancer agent: A review. Crit Rev Food Sci Nutr. 2018 Jun 13;58(9):1428-1447. doi: 10.1080/10408398.2016.1263597. Epub 2017 Jul 21. PMID: 28001084.
5: Breuss JM, Atanasov AG, Uhrin P. Resveratrol and Its Effects on the Vascular System. Int J Mol Sci. 2019 Mar 27;20(7):1523. doi: 10.3390/ijms20071523. PMID: 30934670; PMCID: PMC6479680.
6: Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-Inflammatory Action and Mechanisms of Resveratrol. Molecules. 2021 Jan 5;26(1):229. doi: 10.3390/molecules26010229. PMID: 33466247; PMCID: PMC7796143.
7: Kataria R, Khatkar A. Resveratrol in Various Pockets: A Review. Curr Top Med Chem. 2019;19(2):116-122. doi: 10.2174/1568026619666190301173958. PMID: 30834833.
8: Singh AP, Singh R, Verma SS, Rai V, Kaschula CH, Maiti P, Gupta SC. Health benefits of resveratrol: Evidence from clinical studies. Med Res Rev. 2019 Sep;39(5):1851-1891. doi: 10.1002/med.21565. Epub 2019 Feb 11. PMID: 30741437.
9: Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah GK, Pintus G. Potential Adverse Effects of Resveratrol: A Literature Review. Int J Mol Sci. 2020 Mar 18;21(6):2084. doi: 10.3390/ijms21062084. PMID: 32197410; PMCID: PMC7139620.
10: Tian B, Liu J. Resveratrol: a review of plant sources, synthesis, stability, modification and food application. J Sci Food Agric. 2020 Mar 15;100(4):1392-1404. doi: 10.1002/jsfa.10152. Epub 2019 Dec 14. PMID: 31756276.
11: Li H, Xia N, Hasselwander S, Daiber A. Resveratrol and Vascular Function. Int J Mol Sci. 2019 Apr 30;20(9):2155. doi: 10.3390/ijms20092155. PMID: 31052341; PMCID: PMC6539341.
12: Wong RH, Thaung Zaw JJ, Xian CJ, Howe PR. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res. 2020 Nov;35(11):2121-2131. doi: 10.1002/jbmr.4115. Epub 2020 Jul 14. PMID: 32564438; PMCID: PMC7689937.
13: Hecker A, Schellnegger M, Hofmann E, Luze H, Nischwitz SP, Kamolz LP, Kotzbeck P. The impact of resveratrol on skin wound healing, scarring, and aging. Int Wound J. 2022 Jan;19(1):9-28. doi: 10.1111/iwj.13601. Epub 2021 May 5. PMID: 33949795; PMCID: PMC8684849.
14: Nadile M, Retsidou MI, Gioti K, Beloukas A, Tsiani E. Resveratrol against Cervical Cancer: Evidence from In Vitro and In Vivo Studies. Nutrients. 2022 Dec 10;14(24):5273. doi: 10.3390/nu14245273. PMID: 36558430; PMCID: PMC9787601.
15: Zhang LX, Li CX, Kakar MU, Khan MS, Wu PF, Amir RM, Dai DF, Naveed M, Li QY, Saeed M, Shen JQ, Rajput SA, Li JH. Resveratrol (RV): A pharmacological review and call for further research. Biomed Pharmacother. 2021 Nov;143:112164. doi: 10.1016/j.biopha.2021.112164. Epub 2021 Oct 2. PMID: 34649335.
16: Ratz-Łyko A, Arct J. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. J Cosmet Laser Ther. 2019;21(2):84-90. doi: 10.1080/14764172.2018.1469767. Epub 2018 May 8. PMID: 29737899.
17: Annaji M, Poudel I, Boddu SHS, Arnold RD, Tiwari AK, Babu RJ. Resveratrol- loaded nanomedicines for cancer applications. Cancer Rep (Hoboken). 2021 Jun;4(3):e1353. doi: 10.1002/cnr2.1353. Epub 2021 Mar 2. PMID: 33655717; PMCID: PMC8222557.
18: Barber TM, Kabisch S, Randeva HS, Pfeiffer AFH, Weickert MO. Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review. Nutrients. 2022 Jul 13;14(14):2870. doi: 10.3390/nu14142870. PMID: 35889827; PMCID: PMC9320680.
19: Pignet AL, Schellnegger M, Hecker A, Kohlhauser M, Kotzbeck P, Kamolz LP. Resveratrol-Induced Signal Transduction in Wound Healing. Int J Mol Sci. 2021 Nov 23;22(23):12614. doi: 10.3390/ijms222312614. PMID: 34884419; PMCID: PMC8657598.
20: Pyo IS, Yun S, Yoon YE, Choi JW, Lee SJ. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases. Molecules. 2020 Oct 12;25(20):4649. doi: 10.3390/molecules25204649. PMID: 33053864; PMCID: PMC7587336.
Anti-Aging & Longevity
1: Pastor RF, Restani P, Di Lorenzo C, Orgiu F, Teissedre PL, Stockley C, Ruf JC, Quini CI, Garcìa Tejedor N, Gargantini R, Aruani C, Prieto S, Murgo M, Videla R, Penissi A, Iermoli RH. Resveratrol, human health and winemaking perspectives. Crit Rev Food Sci Nutr. 2019;59(8):1237-1255. doi: 10.1080/10408398.2017.1400517. Epub 2017 Dec 5. PMID: 29206058.
2: Chudzińska M, Rogowicz D, Wołowiec Ł, Banach J, Sielski S, Bujak R, Sinkiewicz A, Grześk G. Resveratrol and cardiovascular system-the unfulfilled hopes. Ir J Med Sci. 2021 Aug;190(3):981-986. doi: 10.1007/s11845-020-02441-x. Epub 2020 Nov 21. PMID: 33219913.
3: Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SM. Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials. Pan Afr Med J. 2023 Mar 16;44:134. doi: 10.11604/pamj.2023.44.134.32404. PMID: 37333786; PMCID: PMC10276340.
4: Hipólito-Reis M, Neto AC, Neves D. Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review. Phytother Res. 2022 Jun;36(6):2416-2433. doi: 10.1002/ptr.7464. Epub 2022 May 18. PMID: 35583746.
5: Ibrahim GG, Yan J, Xu L, Yang M, Yan Y. Resveratrol Production in Yeast Hosts: Current Status and Perspectives. Biomolecules. 2021 Jun 2;11(6):830. doi: 10.3390/biom11060830. PMID: 34199540; PMCID: PMC8226833.
6: Zivarpour P, Reiner Ž, Hallajzadeh J, Mirsafaei L. Resveratrol and Cardiac Fibrosis Prevention and Treatment. Curr Pharm Biotechnol. 2022;23(2):190-200. doi: 10.2174/1389201022666210212125003. PMID: 33583368.
7: Agah S, Akbari A, Sadeghi E, Morvaridzadeh M, Basharat Z, Palmowski A, Heshmati J. Resveratrol supplementation and acute pancreatitis: A comprehensive review. Biomed Pharmacother. 2021 May;137:111268. doi: 10.1016/j.biopha.2021.111268. Epub 2021 Jan 22. PMID: 33493966.
8: Toniolo L, Concato M, Giacomello E. Resveratrol, a Multitasking Molecule That Improves Skeletal Muscle Health. Nutrients. 2023 Jul 31;15(15):3413. doi: 10.3390/nu15153413. PMID: 37571349; PMCID: PMC10421121.
9: Olivares-Marin IK, González-Hernández JC, Madrigal-Perez LA. Resveratrol cytotoxicity is energy-dependent. J Food Biochem. 2019 Sep;43(9):e13008. doi: 10.1111/jfbc.13008. Epub 2019 Aug 6. PMID: 31385323.
10: Subhan I, Siddique YH. Resveratrol: Protective Agent Against Alzheimer’s Disease. Cent Nerv Syst Agents Med Chem. 2024;24(3):249-263. doi: 10.2174/0118715249287167240222081517. PMID: 38468523.
11: Grzeczka A, Kordowitzki P. Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes? Nutrients. 2022 Dec 1;14(23):5101. doi: 10.3390/nu14235101. PMID: 36501130; PMCID: PMC9736670.
12: Zaffaroni N, Beretta GL. Resveratrol and Prostate Cancer: The Power of Phytochemicals. Curr Med Chem. 2021;28(24):4845-4862. doi: 10.2174/0929867328666201228124038. PMID: 33371831.
13: Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial. Complement Ther Med. 2022 Jun;66:102819. doi: 10.1016/j.ctim.2022.102819. Epub 2022 Mar 1. PMID: 35240291.
14: Kisková T, Kassayová M. Resveratrol Action on Lipid Metabolism in Cancer. Int J Mol Sci. 2019 Jun 1;20(11):2704. doi: 10.3390/ijms20112704. PMID: 31159437; PMCID: PMC6601040.
15: Davoodvandi A, Sharif PM, Dana PM, Asemi Z. Resveratrol Effects on Molecular Pathways and MicroRNAs in Gastrointestinal Cancers. Curr Med Chem. 2023;30(7):820-840. doi: 10.2174/0929867329666220729153654. PMID: 35909292.
16: Malaguarnera L. Influence of Resveratrol on the Immune Response. Nutrients. 2019 Apr 26;11(5):946. doi: 10.3390/nu11050946. PMID: 31035454; PMCID: PMC6566902.
17: Huang DD, Shi G, Jiang Y, Yao C, Zhu C. A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications. Biomed Pharmacother. 2020 May;125:109767. doi: 10.1016/j.biopha.2019.109767. Epub 2020 Feb 12. PMID: 32058210.
18: Shetty R, Joshi PD, Mahendran K, Jayadev C, Das D. Resveratrol for dry eye disease – Hope or Hype? Indian J Ophthalmol. 2023 Apr;71(4):1270-1275. doi: 10.4103/IJO.IJO_3204_22. PMID: 37026258; PMCID: PMC10276748.
19: Springer M, Moco S. Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients. 2019 Jan 11;11(1):143. doi: 10.3390/nu11010143. PMID: 30641865; PMCID: PMC6357128.
20: Sales JM, Resurreccion AV. Resveratrol in peanuts. Crit Rev Food Sci Nutr. 2014;54(6):734-70. doi: 10.1080/10408398.2011.606928. PMID: 24345046.